Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.

@article{Morillo2017BenznidazoleAP,
  title={Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.},
  author={Carlos A. Morillo and Hetty Waskin and Sergio Sosa-Estani and Maria Del Carmen Bangher and Carlos Alberto Cuneo and Rodolfo Milesi and Marcelo Mallagray and Werner Apt and Juan S Beloscar and J. Gascon and I Garc{\'i}a de la Filia Molina and Luis Eduardo Echeverria and Hugo Colombo and Jos{\'e} Antonio P{\'e}rez-Molina and Fernando Wyss and Brandi Meeks and Laura R Bonilla and Peggy Gao and Bo Wei and Michael K. McCarthy and Salim Yusuf},
  journal={Journal of the American College of Cardiology},
  year={2017},
  volume={69 8},
  pages={939-947}
}
BACKGROUND Benznidazole is recommended for treatment of Chagas infection. Effects of combination therapy with benznidazole and posaconazole have not been tested in Trypanosoma cruzi carriers. OBJECTIVES The purpose of this study was to determine whether posaconazole alone or combined with benznidazole were superior to benznidazole monotherapy in eliminating T. cruzi parasites measured by real time polymerase chain reaction (RT-PCR) in asymptomatic Chagas carriers. METHODS A prospective… CONTINUE READING
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