Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

@article{Trochine2014BenznidazoleBA,
  title={Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics},
  author={Andrea Trochine and Darren John Creek and Paula Faral-Tello and Michael P. Barrett and Carlos Robello},
  journal={PLoS Neglected Tropical Diseases},
  year={2014},
  volume={8}
}
Background The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully understood. In the present work we used a non-targeted MS-based metabolomics approach to study the metabolic response of T. cruzi to Bzn. Methodology/Principal findings Parasites treated with… 

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