Benzidine binding to nucleic acids mediated by the peroxidative activity of prostaglandin endoperoxide synthetase.

Abstract

The cooxidative metabolism of the urinary bladder carcinogen benzidine was examined using renal inner medullary microsomes. The products of [14C]benzidine metabolism were recovered in the aqueous but not in the organic soluble fraction of reacting mixtures. The reactive metabolites formed during cooxidative metabolism of benzidine bound to DNA and transfer… (More)

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