Benzenediol lactones: a class of fungal metabolites with diverse structural features and biological activities.
@article{Shen2015BenzenediolLA, title={Benzenediol lactones: a class of fungal metabolites with diverse structural features and biological activities.}, author={Weiyun Shen and Hongqiang Mao and Qian Huang and Jinyan Dong}, journal={European journal of medicinal chemistry}, year={2015}, volume={97}, pages={ 747-77 } }
55 Citations
Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis
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It is revealed that the founding member of a new glycosyltransferase (GT) family from Beauveria bassiana that is not orthologous to GTs isolated from other fungi is a promiscuous enzyme that efficiently modifies a broad range of drug-like substrates, including polyketides, anthraquinones, flavonoids, and naphthalenes.
Secondary Metabolites of Lasiodiplodia theobromae: Distribution, Chemical Diversity, Bioactivity, and Implications of Their Occurrence
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Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis
- ChemistryArchives of Pharmacal Research
- 2020
In this review, more than 100 RAL-type of compounds are structurally classified into three groups; 14-membered RALs with 17R configuration, 14- Membered RALS with 17S configuration, and benzopyranones/benzofuranones, and they are reviewed comprehensively in terms of chemistry, biological activities, and biosynthetic pathways.
Natural resorcylic acid lactones: a chemical biology approach for anticancer activity.
- Chemistry, BiologyDrug discovery today
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Polyketides from Marine-Derived Aspergillus porosus: Challenges and Opportunities for Determining Absolute Configuration.
- ChemistryJournal of natural products
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The structure elucidation of porosuphenols A-D is presented as a case study in the challenges and opportunities for determination of absolute configuration.
Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1
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The functionally characterized sulfotransferase superfamily is extended to the kingdom Fungi and total biosynthetic and biocatalytic synthetic biological platforms to produce unnatural natural product (uNP) sulfoconjugates are demonstrated.
Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives
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- 2021
Combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy, not only for environmentally friendly antifoulants but also for structurally novel drugs.
Bioactive Resorcylic Acid Lactones with Different Ring Systems from Desert Plant Chaetosphaeronema hispidulum. [corrected].
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Five new resorcylic acid lactones (RALs) hispidulactones A-E, a new natural product (2), and four known ones with different ring systems were isolated from the desert plant Chaetosphaeronema hispidulum and displayed strongly biological effects on the seedlings growth with a dose-dependent relationship.
Hyalodendriellins A–F, new 14-membered resorcylic acid lactones from the endophytic fungus Hyalodendriella sp. Ponipodef12
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Six new 14-membered resorcylic acid lactones (RALs) were isolated from the culture of the endophytic fungus Hyalodendriella sp.
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