Benzene-specific increase in leukocyte alkaline phosphatase activity in rats exposed to vapors of various organic solvents.

@article{Li1986BenzenespecificII,
  title={Benzene-specific increase in leukocyte alkaline phosphatase activity in rats exposed to vapors of various organic solvents.},
  author={Guilan L. Li and Songnian N. Yin and Takao Watanabe and Haruo Nakatsuka and Masato Kasahara and Hiroshi Abe and Masayuki Ikeda},
  journal={Journal of toxicology and environmental health},
  year={1986},
  volume={19 4},
  pages={581-9}
}
Female Wistar rats were exposed to various solvent vapors 8 h/d for 7 d. The leukocyte suspension and serum were prepared from peripheral blood and utilized for the determination of alkaline phosphatase (AP) activity with disodium phenyl phosphate as a substrate [leukocyte AP (LAP) and serum AP (SAP) assay]. While the exposure to benzene at 20 or 50 ppm did not cause significant changes in LAP activity, the exposure at 100 and 300 ppm resulted in a dose-dependent increase of LAP activity up to… CONTINUE READING