Benzene hemoglobin adducts in mice and rats: characterization of formation and physiological modeling.

@article{Sun1990BenzeneHA,
  title={Benzene hemoglobin adducts in mice and rats: characterization of formation and physiological modeling.},
  author={James D. Sun and Michele Medinsky and Linda S Birnbaum and Gary Lucier and Rogene F. Henderson},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1990},
  volume={15 3},
  pages={468-75}
}
Benzene is a myelotoxin and a human leukemogen. Humans are exposed to this compound, both occupationally and environmentally. This study was conducted to determine whether formation of benzene-derived adducts with blood hemoglobin (Hb) can be used as a biomarker of exposure to benzene. B6C3F1 mice and F344/N rats were given 0.1 to 10,000 mumol [14C]benzene/kg body wt, orally. Twenty-four hours later, animals were euthanized, and globin was isolated from blood samples. The globin was analyzed by… CONTINUE READING

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