Benzazepine metabolism revisited. Evidence for the formation of novel amine conjugates.

@article{Straub1988BenzazepineMR,
  title={Benzazepine metabolism revisited. Evidence for the formation of novel amine conjugates.},
  author={Kenneth M Straub and Melanie D Davis and B Y Hwang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1988},
  volume={16 3},
  pages={359-66}
}
Three novel metabolites of the benzazepine SK&F 86466 (6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine) have been isolated from dog urine and characterized by tandem mass spectrometry, using fast atom bombardment and thermospray ionization, and 1H and 13C NMR spectroscopy. The parent drug undergoes oxidation to yield an N-oxide or N-demethylation to yield the primary metabolite SK&F 101055 (6-chloro-2,3,4,5-tetrahydro-1H-3-benzazepine). This desmethyl metabolite then undergoes N… CONTINUE READING
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