Bent domain structure of recombinant human IgE-Fc in solution by X-ray and neutron scattering in conjunction with an automated curve fitting procedure.

@article{Beavil1995BentDS,
  title={Bent domain structure of recombinant human IgE-Fc in solution by X-ray and neutron scattering in conjunction with an automated curve fitting procedure.},
  author={Andrew J Beavil and Rose J Young and Brian J. Sutton and Stephen J Perkins},
  journal={Biochemistry},
  year={1995},
  volume={34 44},
  pages={14449-61}
}
Human immunoglobulin E (IgE) consists of 14 domains, each with the characteristic immunoglobulin fold structure. Compared with the 12-domain structure of immunoglobulin G (IgG), IgE has an additional pair of domains (C epsilon 2) in the Fc region in place of the hinge of IgG. The crystal structure of the 4-domain Fc fragment of IgG is known, but not that of the 6-domain Fc fragment of IgE (IgE-Fc). In order to elucidate the position of the C epsilon 2 domains in the domain structure of IgE-Fc… CONTINUE READING

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