Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro.

@article{Palmoski1983BenoxaprofenSP,
  title={Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro.},
  author={Marshall J. Palmoski and Kenneth D. Brandt},
  journal={Arthritis and rheumatism},
  year={1983},
  volume={26 6},
  pages={
          771-4
        }
}
Several nonsteroidal antiinflammatory drugs which are cyclooxygenase inhibitors (e.g., salicylates, fenoprofen, ibuprofen) have been shown to suppress proteoglycan synthesis by normal joint cartilage in vitro. We examined the effect of benoxaprofen, a long-acting proprionic acid derivative which inhibits lipoxygenase in addition to causing moderate cyclooxygenase inhibition. When added to the culture medium in concentrations comparable with those obtainable in serum of patients treated with the… Expand
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