Benoxaprofen-induced photo-onycholysis.

  title={Benoxaprofen-induced photo-onycholysis.},
  author={L S McCormack and Mervyn L. Elgart and Maria L Chanco Turner},
  journal={Journal of the American Academy of Dermatology},
  volume={7 5},
Spontaneous Photo‐onycholysis
  • T. Horio
  • Medicine
    The Journal of dermatology
  • 1988
The observations strongly suggest the role of sunlight and exclude involvement of any photosensitizing drug in this disorder.
Nail Reactions to Antibiotics, Antimalarials, and Other Medications
Many drug classes have been associated with drug-induced nail abnormalities, including antimicrobials, antimalarials, cardiovascular agents, anti-inflammatories, antirheumatics, hormones,
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
Syringomatous hyperplasia and eccrine squamous syringometaplasia associated with benoxaprofen therapy.
Two patients are described, each of whom developed multiple eruptive lesions on sun-exposed areas within days after starting benoxaprofen therapy, and microscopically showed squamous metaplasia of eccrine ducts and focal necrosis of Eccrine keratinocytes as well as prominent eccrine hyperplasia.
Photosensitivity Due to Nonsteroidal Antiinflammatory Drugs
Until now the number of clinically used nonsteroidal antiinflammatory drugs (NSAID) increased up to fourty. Some of these NSAID are known to exert photosensitizing effects.
Photoreactivity of the Nonsteroidal Anti-inflammatory 2-Arylpropionic Acids with Photosensitizing Side Effects¶
Abstract The photoreactivity of the nonsteroidal anti-inflammatory 2-arylpropionic acids benoxaprofen, carprofen, naproxen, ketoprofen, tiaprofenic acid, and suprofen is reviewed with special
Drug-Induced Nail Disorders
A large number of drugs of different classes, ranging from antibacterials to chemotherapeutic agents to psoralens, can be responsible for the development of nail changes, which are usually transitory and disappear with drug withdrawal, but sometimes persist in time.
Nail changes secondary to systemic drugs or ingestants.


Photo-onycholysis from minocycline. Side effects of minocycline therapy.
This appears to be first report of photo-onycholysis due to minocycline, reported to occur in patients taking tetracycline or a member of the tetrACYcline group of antibiotics, of which minocyCline is a member.
Photo-onycholysis due to tetracycline hydrochloride and doxycycline.
Three cases of this phenomenon occurred following the ingestion of either tetracycline hydrochloride or doxycycline (Vibramycin), with two patients, being lifeguards, being shoeless for a considerable portion of each day.
Photosensitivity and photo-onycholysis due to demethylchlortetracycline.
The incidence of photosensitivity with onycholysis due to medications has been remarkably low and, to the authors' knowledge, restricted to chlortetracycline (Aureomycin).
Long-term safety of benoxaprofen.
Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0.4% of the patients or 1 ulcer for 200 patient years.
  • L. Ray
  • Medicine
    Archives of dermatology
  • 1963
Therapy consisting of clipping away the affected nail, cleansing, and applying an antimicrobial and antifungal agent was successful in healing 16 of 27 cases and other antimicrobial agents of sufficiently wide range could be equally successful when combined with thorough debridement and cleansing of the involved nail areas.
Phototoxicity to benoxaprofen.
Photosensitivity to benoxaprofen is typically an immediate-type, short-lived reaction, dominated by subjective sensations of burning-smarting and redness, of the phototoxic type.
Benoxaprofen: once a day vs twice a day in patients with rheumatoid arthritis or osteoarthritis.
The results of the double-blind crossover studies demonstrated the effectiveness of the qd and bid dose and revealed no significant difference between the 2 dose regimens.
An update on long-term efficacy and safety with benoxaprofen.
In long-term, double-blind, parallel studies, benoxaprofen administered as a single daily dose was more efficacious than multiple daily doses of aspirin or ibuprofen.
Effects of benoxaprofen and indomethacin on platelet function and biochemistry.
It is suggested that benoxaprofen, which does not appreciably suppress hemostatic function, may be used safely in patients with acquired or congenital coagulation defects (e.g. patients receiving oral anticoagulant, hemophiliacs with arthropathy).
The pharmacology of benoxaprofen (2‐[4‐chlorophenyl]‐α‐methyl‐5‐benzoxazole acetic acid), LRCL 3794, a new compound with anti‐inflammatory activity apparently unrelated to inhibition of prostaglandin synthesis
Benoxaprofen has analgesic activity in tests where pain is accompanied by inflammation but not in other experimental models of pain, and its low ulcerogenic potential in animal models may be related to its relative inability to inhibit PG synthetase.