Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.

@article{KuleszMartin1988BenignAM,
  title={Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.},
  author={Molly Kulesz-Martin and Remedios M Penetrante and Christopher J. East},
  journal={Carcinogenesis},
  year={1988},
  volume={9 1},
  pages={171-4}
}
Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.