Benidipine : A New Ca 2 + Channel Blocker with a Cardioprotective Effect

@inproceedings{Kitakaze1999BenidipineA,
  title={Benidipine : A New Ca 2 + Channel Blocker with a Cardioprotective Effect},
  author={Masafumi Kitakaze and Akira Karasawa and Hiroyuki Kobayashi and Hiroyuki Tanaka and Tsunehiko Kuzuya and Masatsugu Hori},
  year={1999}
}
Ca channel blockers are widely used for the treatment of ischemic heart disease and systemic hypertension because of their ability to effectively dilate coronary and systemic arteries (30,44). Ca 2+ channel blockers increase coronary blood flow (CBF) in inhibiting Ca entry into smooth muscle cells (48). Since Ca 2+ overload is deleterious for the maintenance of cellular homeostasis, Ca 2+ channel blockers are believed to be effective in attenuating Ca 2+ overload. However, Ca 2+ overload in… CONTINUE READING