Corpus ID: 39735184

Benfotiamine. Monograph.

  title={Benfotiamine. Monograph.},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  volume={11 3},
  • Published 2006
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
Introduction Neurological disorders, particularly diabetic neuropathy, have been treated with vitamin B1 (thiamine) for decades; however, the bioavailability of orally administered, water-soluble thiamine salts is low compared to fat-soluble analogs. For treatment to be successful, high levels of thiamine are needed in both blood and tissues. In 1954, Fujiwara discovered a group of lipid-soluble thiamine derivatives, subsequently named allithiamines because they occur naturally in Allium family… Expand
3 Citations
Therapeutic potential of benfotiamine and its molecular targets.
In the present review, a comprehensively reviewed all the molecular targets modulated by BFT to provide mechanistic perspective to highlight its pleiotropic effects. Expand
Benfotiamine European Supplement Protects Against Diabetic Complications
Used for decades in Europe as a prescription medication, benfotiamine ameliorates the progression of diabetic nerve, kidney, and retinal damage, and relieves the painful symptoms of diabeticExpand
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1.
The results suggest that benfotiamine suppresses oxidative stress-induced NF-kappaB-dependent inflammatory signaling leading to uveitis, and could be used as a novel therapeutic agent for the treatment of ocular inflammation, especially Uveitis. Expand


Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
High-dose thiamine and benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy and countered the accumulation of triosephosphates in experimental diabetes and inhibited the development of incipient nephtropathy. Expand
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and NF-κB activation by activating transketolase, and also prevented experimental diabetic retinopathy, which might be clinically useful in preventing the development and progression of diabetic complications. Expand
Comparative bioavailability of various thiamine derivatives after oral administration.
  • A. Greb, R. Bitsch
  • Chemistry, Medicine
  • International journal of clinical pharmacology and therapeutics
  • 1998
Oral administration of benfotiamin is best suitable for therapeutical purposes owing to its excellent absorption characteristics and significantly improved thiamine bioavailability from benfOTiamin compared with the other preparations. Expand
Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose
Benfotiamine, a derivative of thiamine with better bioavailability, corrects defective replication and increased AGE generation in endothelial cells cultured in high glucose, to a similar extent asThiamine. Expand
Pharmacokinetics of thiamine derivatives especially of benfotiamine.
  • D. Loew
  • Chemistry, Medicine
  • International journal of clinical pharmacology and therapeutics
  • 1996
It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts and should be preferred in treatment of relevant indications. Expand
Regulation of Intracellular Glucose and Polyol Pathway by Thiamine and Benfotiamine in Vascular Cells Cultured in High Glucose*
The effects of thiamine and benfotiamine on the polyol pathway, transketolase activity, and intracellular glucose in endothelial cells and pericytes under high ambient glucose are verified to justify testingThiamine as a potential approach to the prevention and/or treatment of diabetic complications. Expand
Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative.
A superior cellular efficacy of benfotiamine was concluded from the short-term stimulation of the thiamin-dependent transketolase activity in erythrocytes and a significantly improved bioavailability from the lipophilic derivative was demonstrated. Expand
Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis
It is demonstrated, for the first time, that benfotiamine aids the post-ischaemic healing of diabetic animals via PKB/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. Expand
Erythrocyte transketolase activity in patients with chronic renal disease.
The magnitude of activity increases as a result of TPP saturation which is probably indicative of an insignificant thiamine deficiency in patients with chronic uraemia. Expand
Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose
The effects of thiamine and benfotiamine on cell cycle, apoptosis, and expression of adhesion molecules in endothelial cells and pericytes, under high ambient glucose are verified. Expand