Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.

@article{Stirban2006BenfotiaminePM,
  title={Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.},
  author={Alin O Stirban and Monica Negrean and Bernd Stratmann and Thomas Gawlowski and Tina Horstmann and Christian G{\"o}tting and Knut Kleesiek and Michaela Mueller-Roesel and Theodor Koschinsky and Jaime Uribarri and Helen Vlassara and Diethelm Tschoepe},
  journal={Diabetes care},
  year={2006},
  volume={29 9},
  pages={2064-71}
}
OBJECTIVE Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on postprandial endothelial dysfunction and MG synthesis have not been investigated in humans until now. RESEARCH DESIGN AND METHODS… CONTINUE READING
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