Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

@article{Volvert2008BenfotiamineAS,
  title={Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives},
  author={Marie-Laure Volvert and Sandrine R.M. Seyen and Marie Piette and Brigitte Evrard and Marjorie Gangolf and Jean Christophe Plumier and Lucien Bettendorff},
  journal={BMC Pharmacology},
  year={2008},
  volume={8},
  pages={10 - 10}
}
BackgroundLipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine diphosphate and so enhancing transketolase activity. As the brain is particularly sensitive to thiamine deficiency, we wanted to test whether… Expand
Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride
TLDR
The results showed that thiamine and its phosphorylated metabolites exhibited different pharmacokinetic characteristics in plasma, blood and erythrocyte, and one‐compartment model provided the best fit for pharmacokinetics profiles of thiamines. Expand
Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine
TLDR
In vitro studies show that another thiamine thioester, dibenzoylthiamine (DBT) is even more efficient that BFT, especially with respect to its anti-inflammatory potency. Expand
Therapeutic potential of benfotiamine and its molecular targets.
TLDR
In the present review, a comprehensively reviewed all the molecular targets modulated by BFT to provide mechanistic perspective to highlight its pleiotropic effects. Expand
The multifaceted therapeutic potential of benfotiamine.
TLDR
The present review critically analyzed the multifaceted therapeutic potential of benfotiamine and found it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. Expand
Biological functions of thiamine derivatives: focus on non-coenzyme roles
TLDR
There is now growing evidence in favour of the existence of thiamine-binding proteins with specific roles in the nervous system, possibly in the regulation of neurotransmitter release, and some of its synthetic precursors with higher bioavailability have beneficial effects in several models of Alzheimer’s disease and may be beneficial for patients suffering from Alzheimer's or Parkinson's diseases. Expand
Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration
TLDR
Results suggest that benfotiamine could be a potential therapeutic approach in the treatment of sporadic AD, with an increased amount of Glun2b subunit of NMDA receptors, decreased inflammation, and improvement of cognitive deficit. Expand
Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration.
  • G. Portari, H. Vannucchi, A. Jordão
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2013
TLDR
The high bioavailability especially of benfotiamine within 6h of ethanol administration was verified, confirming the effective treatment given to rats with acute alcohol intoxication in increasing thiamine levels in plasma, erythrocytes and liver cells. Expand
Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine Hurt
Thiamine (Vitamin B1) is an essential vitamin that must be obtained from the diet for proper neurological function. At higher doses, thiamine and benfotiamine (S-benzoylthiamine O-monophosphate,Expand
Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine
TLDR
This study found that Prostatic acid phosphatase (PAP, ACPP) can dephosphorylate BT in vitro, in dorsal root ganglia (DRG) neurons and in primary-afferent axon terminals in the dorsal spinal cord, and suggests a novel phosphat enzyme-independent function for PAP. Expand
Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism
Background Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models ofExpand
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