Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients. A double-blind, randomized, placebo-controlled study.

@article{Comet2006BenefitsOL,
  title={Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients. A double-blind, randomized, placebo-controlled study.},
  author={Ricard Comet and Christian Domingo and M. J. Cubells Larrosa and A. Mor{\'o}n and Montserrat Ru{\'e} and Mar{\'i}a-Jos{\'e} Amengual and A S{\'a}nchez Mar{\'i}n},
  journal={Respiratory medicine},
  year={2006},
  volume={100 3},
  pages={411-9}
}
BACKGROUND Though several drugs have been tested, the choice of the ideal steroid-sparing agent in steroid-dependent asthmatic patients remains unclear. Our objective was to evaluate the efficacy and tolerance of methotrexate in low weekly doses in order to decrease chronic oral steroid requirements in asthmatic patients. METHODS DESIGN double blind randomized placebo-controlled study. SETTING The study was performed in a 760-bed teaching hospital. PATIENTS 46 steroid-dependent… CONTINUE READING