Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review

@article{Lee2021BenefitsOC,
  title={Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review},
  author={Young Ran Lee and Kandace Vo and Jincy Thazhampallatu Varughese},
  journal={Nutrition and Health},
  year={2021},
  volume={28},
  pages={77 - 93}
}
Background: Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality. Recently, the combination of hydrocortisone, ascorbic acid and thiamine (HAT) was hypothesized to work synergistically to reverse septic shock and reduce mortality. Aim: To ascertain the efficacy of HAT therapy and compare whether HAT therapy is more beneficial compared to the standard of care in sepsis and septic shock patients. Methods: PubMed, Clinicaltrials.gov… 
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Figures and Tables from this paper

Insights Into Thiamine Supplementation in Patients With Septic Shock

TLDR
The association of thiamine, vitamin C and corticoids was tested as an adjunctive therapy in septic shock resulting in a significant decrease in mortality but after these initial results, no other study conducted with this combination could reproduce those benefits.

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TLDR
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TLDR
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