Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions

@inproceedings{Hiroi2016BenefitsOH,
  title={Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions},
  author={Ryoko Hiroi and Giulia Weyrich and Stephanie V. Koebele and Sarah E. Mennenga and Joshua S. Talboom and Lauren T. Hewitt and Courtney N. Lavery and Perla Mendoza and Ambra Jordan and Heather A. Bimonte-Nelson},
  booktitle={Front. Neurosci.},
  year={2016}
}
Decreased serotonin (5-HT) function is associated with numerous cognitive and affective disorders. Women are more vulnerable to these disorders and have a lower rate of 5-HT synthesis than men. Serotonergic neurons in the dorsal raphe nucleus (DRN) are a major source of 5-HT in the forebrain and play a critical role in regulation of stress-related disorders… CONTINUE READING