Benefits and unintended consequences of antimicrobial de-escalation: Implications for stewardship programs

Abstract

Sequential antimicrobial de-escalation aims to minimize resistance to high-value broad-spectrum empiric antimicrobials by switching to alternative drugs when testing confirms susceptibility. Though widely practiced, the effects de-escalation are not well understood. Definitions of interventions and outcomes differ among studies. We use mathematical models… (More)
DOI: 10.1371/journal.pone.0171218

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