Benefits and Risks of Pharmacological Agents Used for the Treatment of Menorrhagia

@article{Roy2004BenefitsAR,
  title={Benefits and Risks of Pharmacological Agents Used for the Treatment of Menorrhagia},
  author={Samendra Nath Roy and Siladitya Bhattacharya},
  journal={Drug Safety},
  year={2004},
  volume={27},
  pages={75-90}
}
Menorrhagia affects the lives of many women. The assessment of menstrual flow is highly subjective and gauging the severity of the condition by objective assessment of menstrual blood loss is impractical. In treating menorrhagia, the primary aim should be to improve quality of life. Women are willing to undergo quite invasive treatment in order to achieve this. Drug therapy is the initial treatment of choice and the only option for those who wish to preserve their reproductive function. Despite… Expand
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References

SHOWING 1-10 OF 90 REFERENCES
Risk-Benefit Assessment of Drugs Used for the Treatment of Menstrual Disorders
TLDR
The therapeutic alternatives which are commonly prescribed in an attempt to rectify such menstrual disorders are discussed and the results of clinical trials which have utilised these various agents are considered in terms of both the effectiveness of treatment and its potential adverse effects. Expand
Medical management of menorrhagia
TLDR
Of the drugs available, mefenamic acid and tranexamic acid have been used most often, and consistently reduce MBL by about 25% and 50% respectively, and are appropriate first-line drugs for the treatment of DUB; fibrinolytic inhibitors appear to be more effective, but adverse effects are more common. Expand
Medical management of menorrhagia
TLDR
In the management of excessive menstrual loss there is good evidence that many doctors do not necessarily prescribe the most effective treatments, whereas only 1 in 20 prescribe tranexamic acid—probably the mosteffective first line treatment. Expand
Treating menorrhagia in primary care. An overview of drug trials and a survey of prescribing practice.
TLDR
Treatment of menorrhagia in primary care falls short of desirable standards, and a meta-analysis of randomized trials of drug therapy revealed wide differences in efficacy and side effects. Expand
Efficacy of Mefenamic Acid in Patients with a Complaint of Menorrhagia
TLDR
There was an indication based on small sample sizes that mefenamic acid reduced blood loss in women with anovulatory dysfunctional uterine bleeding, fibroids, intrauterine devices, and von Willebrand disease. Expand
Management of cyclical menorrhagia with prostaglandin synthetase inhibitor.
TLDR
Mefenamic acid proved to be a potent and efficacious agent in the control of unexplained menorrhagia and caused significant reduction in the number of days of bleeding. Expand
Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid
TLDR
Tranexamic acid given during menstruation is a safe and highly effective treatment for excessive bleeding and should be offered to women with dysfunctional bleeding before a decision is made about surgery. Expand
A survey of different approaches to management of menstrual disturbances in women using injectable contraceptives.
TLDR
It is clear that the bleeding disturbances associated with DMPA and NET-EN use are poorly understood and that urgent research is necessary to clarify pathophysiological mechanisms and improve management. Expand
REDUCTION OF MENSTRUAL BLOOD LOSS BY DANAZOL IN UNEXPLAINED MENORRHAGIA: LACK OF EFFECT OF PLACEBO
TLDR
The results suggest that 200 mg danazol daily is the most acceptable regimen clinically since it significantly reduced menstrual blood loss and was associated with a relatively low incidence of side effects. Expand
The Effects of Mefenamic Acid and Norethisterone on Measured Menstrual Blood Loss
TLDR
It is concluded that mefenamic acid and norethisterone were similarly effective in reducing the degree of menstrual blood loss in women with proved menorrhagia, but that 52 and 67% of the women, respectively, remainedMenorrhagic after 2 months of treatment. Expand
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