Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis.

@article{Chritin2006BenefitOT,
  title={Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis.},
  author={Muriel Chritin and Marc Savasta and G Erard Besson},
  journal={Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases},
  year={2006},
  volume={7 1},
  pages={32-7}
}
The familial form of amyotrophic lateral sclerosis (FALS) has been linked in some cases to dominant mutations in the gene encoding the Cu/Zn superoxide dismutase (SOD1) mutation. Transgenic mice bearing the G93A SOD1 mutation develop clinical symptoms and pathological features similar to those described in the human disease and represent a good model to explore the potential benefit of therapeutic agents. Using this animal model, we tested the efficacy of morphine and tianeptine treatments… CONTINUE READING