Benefit of carotid endarterectomy for symptomatic and asymptomatic severe carotid artery stenosis: a Markov model based on data from randomized controlled trials. Clinical article.

@article{Nagaki2009BenefitOC,
  title={Benefit of carotid endarterectomy for symptomatic and asymptomatic severe carotid artery stenosis: a Markov model based on data from randomized controlled trials. Clinical article.},
  author={Tomohito Nagaki and Koji Sato and Takaaki Yoshida and Yuhei Yoshimoto},
  journal={Journal of neurosurgery},
  year={2009},
  volume={111 5},
  pages={
          970-7
        }
}
OBJECT Several major randomized controlled trials of carotid endarterectomy (CEA) in patients with both symptomatic and asymptomatic carotid artery stenosis have addressed the net effects of CEA on the risk of stroke. However, because the risk of stroke among patients with asymptomatic carotid stenosis is relatively low, whether to treat their stenosis with CEA remains an important public health issue. METHODS The authors constructed a Markov model to evaluate the effectiveness of CEA. In… 
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TLDR
CEA is helpful for recently symptomatic patients with carotid artery stenosis ≥50% (NASCET technique) but adds no benefit in terms of stroke/death for asymptomatic patients.
Obesity is an independent risk factor for death and cardiac complications after carotid endarterectomy.
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TLDR
The generic relationship between immediate risk, long-term benefit, and life expectancy for any one-time prophylactic treatment is model and then applied to the use of revascularization in the management of asymptomatic carotid disease.
Update on Surgical Management for Asymptomatic Carotid Stenosis
TLDR
Overall, the current recommendation is for surgical management of asymptomatic carotid disease for stenoses ≥ 80% in patients who are of reasonable perioperative risk.
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TLDR
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A method of decision analysis quantifying the effects of age and comorbidities on the probability of deriving significant benefit from medical treatments
TLDR
The effects of age and comorbidity on the probability of deriving significant treatment benefits can be quantified for any individual and even without consideration of other factors affecting external validity, these effects may be sufficient to guide decision-making.
A potential pathway for managing diabetic patients with arterial emboli detected by retinal screening.
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TLDR
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TLDR
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