Benefit-Risk Assessment of Zaleplon in the Treatment of Insomnia

@article{Barbera2005BenefitRiskAO,
  title={Benefit-Risk Assessment of Zaleplon in the Treatment of Insomnia},
  author={Joseph Barbera and Colin Shapiro},
  journal={Drug Safety},
  year={2005},
  volume={28},
  pages={301-318}
}
Insomnia is a heterogeneous, highly prevalent condition that is associated with a high level of psychiatric, physical, social and economic morbidity. The treatment of insomnia involves pharmacological and non-pharmacological interventions. The mainstay of pharmacological treatment of insomnia has been the benzodiazepines, the introduction of which represented a significant improvement over the barbiturates and chloral hydrate. Although benzodiazepines have been shown to be efficacious in… 
Clinical evaluation of zaleplon in the treatment of insomnia
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Though Z-drugs have improved pharmacokinetic profiles, their adverse effects, neuropsychiatric sequelae, and incidence of poisoning and death may prove to be similar to older hypnotics.
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TLDR
Evaluated efficacy of the proprietary formulation E-IN-05 on improving the sleep quality; Sleep Onset Latency; Sleep Efficiency; Sleep Duration and Day Enthusiasm level and its application in insomnia patients.
Insomnia in older people
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Clinicians need to be more aware of their patients' sleep and conduct formal assessments as appropriate, and non-pharmacological treatments should be considered first for chronic insomnia as a means to reduce dependency, adverse effects, and polypharmacy.
Rebound and withdrawal with benzodiazepine and non-benzodiazepine hypnotic medication
TLDR
The purpose of this chapter is to review briefly the clinical problems that can be encountered when discontinuing hypnotic drugs within the normal therapeutic context.
Reviews: Diagnosis and Management of Insomnia in Dialysis Patients
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The diagnosis of sleep disorders with a focus on insomnia in patients on dialysis is reviewed, with only a few studies specifically addressing the management of this sleep disorder in patients with chronic renal disease.
Main neuroendocrine features and therapy in primary sleep troubles.
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Non-benzodiazepine hypnotics were created--zolpidem, zaleplon, which are as effective as benzodiazepines, but have fewer side effects, Nevertheless the use of these hypnotics is also restricted to 7-10 days.
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