Benefit/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis.

Abstract

BACKGROUND The Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial examined the safety and efficacy of drotrecogin alfa (activated) (Xigris) in adult patients with severe sepsis. A clinical evaluation committee examined clinical data for each patient enrolled in PROWESS. However, there were no surgeons on the committee, and thus questions… (More)

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