Beneficial vs. detrimental actions of ethanol on heart and coronary vascular muscle: roles of Mg2+ and Ca2+.

@article{Altura1996BeneficialVD,
  title={Beneficial vs. detrimental actions of ethanol on heart and coronary vascular muscle: roles of Mg2+ and Ca2+.},
  author={Burton M. Altura and Linyun Zou and Bella T. Altura and Linda A. Jelicks and Beatrice A. Wittenberg and Rajesh K. Gupta},
  journal={Alcohol},
  year={1996},
  volume={13 5},
  pages={499-513}
}
Epidemiologic studies suggest that daily ingestion of small amounts of alcohol may protect the heart, whereas higher intake may be detrimental. We studied: 1) cardiac performance, bioenergetics, and [Mg2+]i of isolated working rat hearts during perfusion with Krebs-Henseleit medium containing different concentrations of ethanol (EtOH), 2) mechanical responses. Ca2+ metabolism and Mg content of isolated coronary arteries obtained from dogs, sheep, and piglets subjected to varying concentrations… CONTINUE READING