Beneficial role for folate in the prevention of colorectal and breast cancer

@article{PrinzLangenohl2001BeneficialRF,
  title={Beneficial role for folate in the prevention of colorectal and breast cancer},
  author={Reinhild Prinz-Langenohl and Iris Fohr and Klaus F. Pietrzik},
  journal={European Journal of Nutrition},
  year={2001},
  volume={40},
  pages={98-105}
}
Summary Folate is involved in the synthesis of nucleotides and amino acid metabolism such as methylation of homocysteine to methionine. Methionine is activated by adenosine triphosphate (ATP) to produce S-adenosylmethionine (SAM), the primary intracellular methyl donor. Thus, folate is essential for the synthesis, methylation, and repair of DNA. With regard to its biochemical function it has been hypothesized that a diminished folate status may contribute to carcinogenesis by alteration of gene… 

Folate, DNA stability and colo-rectal neoplasia

Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both DNA stability and cytosine methylation.

Folate, DNA stability and colo-rectal neoplasia.

Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both DNA stability and cytosine methylation.

Folate metabolism in the human colon: cellular responses identified through in vitro studies

Gene expression analysis revealed that high PGA concentrations increased energy metabolism and lowered iron metabolism related genes in the human colorectal cell line, HT29, and this may suggest a more beneficial effect of MTHF as compared to PGA.

Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature

Overall, maternal folic acid supplementation before and during pregnancy seems to confer protection against the risk of childhood leukaemia in the offspring, with particular emphasis on DNA methylation modifications.

Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer

This study indicates that ACRC patients receiving chemotherapy do not need supplementation with vitamin B12 and folate and that patients with ACRC seem to have fairly adequate cobalamin and folates status before and during chemotherapy treatment.

Associations between Genes in the One-Carbon Metabolism Pathway and Advanced Colorectal Adenoma Risk in Individuals with Low Folate Intake

Stratification by dietary folate and application of the ARTP method revealed statistically significant pathway- and gene-level associations between one-carbon metabolism genes and risk of advanced colorectal adenoma, which were not apparent in analysis of the entire population.

Polymorphisms in the MTHFR and VDR genes and skin cancer risk.

A possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development is suggested, especially for SCC.

Gene-Diet Interaction: DNA Repair Gene, Folate Status and Breast Cancer Risk

Data from a nested case-control study within the Nurses’ Health Study give some support to the hypothesis that genetic variations in DNA repair genes modify the relation between plasma folate level and breast cancer risk.

Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk.

Data give some support for the hypothesis that genetic variations in DNA repair genes may modify the relation between plasma folate level and breast cancer risk.
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