Beneficial role for folate in the prevention of colorectal and breast cancer

  title={Beneficial role for folate in the prevention of colorectal and breast cancer},
  author={Reinhild Prinz-Langenohl and Iris Fohr and Klaus F. Pietrzik},
  journal={European Journal of Nutrition},
Summary Folate is involved in the synthesis of nucleotides and amino acid metabolism such as methylation of homocysteine to methionine. Methionine is activated by adenosine triphosphate (ATP) to produce S-adenosylmethionine (SAM), the primary intracellular methyl donor. Thus, folate is essential for the synthesis, methylation, and repair of DNA. With regard to its biochemical function it has been hypothesized that a diminished folate status may contribute to carcinogenesis by alteration of gene… 

Folate, DNA stability and colo-rectal neoplasia

Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both DNA stability and cytosine methylation.

Folate, DNA stability and colo-rectal neoplasia.

Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both DNA stability and cytosine methylation.

Folate metabolism in the human colon: cellular responses identified through in vitro studies

Gene expression analysis revealed that high PGA concentrations increased energy metabolism and lowered iron metabolism related genes in the human colorectal cell line, HT29, and this may suggest a more beneficial effect of MTHF as compared to PGA.

Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature

Overall, maternal folic acid supplementation before and during pregnancy seems to confer protection against the risk of childhood leukaemia in the offspring, with particular emphasis on DNA methylation modifications.

Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer

This study indicates that ACRC patients receiving chemotherapy do not need supplementation with vitamin B12 and folate and that patients with ACRC seem to have fairly adequate cobalamin and folates status before and during chemotherapy treatment.

Associations between Genes in the One-Carbon Metabolism Pathway and Advanced Colorectal Adenoma Risk in Individuals with Low Folate Intake

Stratification by dietary folate and application of the ARTP method revealed statistically significant pathway- and gene-level associations between one-carbon metabolism genes and risk of advanced colorectal adenoma, which were not apparent in analysis of the entire population.

Polymorphisms in the MTHFR and VDR genes and skin cancer risk.

A possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development is suggested, especially for SCC.

Gene-Diet Interaction: DNA Repair Gene, Folate Status and Breast Cancer Risk

Data from a nested case-control study within the Nurses’ Health Study give some support to the hypothesis that genetic variations in DNA repair genes modify the relation between plasma folate level and breast cancer risk.

Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk.

Data give some support for the hypothesis that genetic variations in DNA repair genes may modify the relation between plasma folate level and breast cancer risk.



Multivitamin Use, Folate, and Colon Cancer in Women in the Nurses' Health Study

This report examines the temporal and dosage relations between intake of folate, both from supplements and from foods, and risk for colon cancer in women in the Nurses' Health Study and pays particular attention to the problem of possible confounding by multivitamin use.

Folate, methionine, and alcohol intake and risk of colorectal adenoma.

Folate, alcohol, and methionine could influence methyl group availability, and a methyl-deficient diet may be linked to early stages of colorectal neoplasia, which supports efforts to increase dietary folate in segments of the population having diets with low intakes of this nutrient.

Dietary folate consumption and breast cancer risk.

The association between dietary folate intake and breast cancer risk and its modification by methionine and alcohol intake in a cohort study in Canada was examined.

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Support is provided for an important role of folate metabolism in colon carcinogenesis and suggests that the 677C-->IT mutation in MTHFR reduces colon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but that low folate intake or high alcohol consumption may negate some of the protective effect.

Folate intake and carcinogenesis of the colon and rectum.

It appears that intake of folate or a correlated factor may be negatively related to risk of rectal cancer, and there was an indication of an interaction between folate and alcohol intake.

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.

DNA methylation status may be used as a functional indicator of moderately depleted folate status and the slow response to the repletion diets observed suggests that normalization of DNA methylation after moderate folate depletion may be delayed in older women.

Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men.

The hypothesis that substantial consumption of alcohol, when combined with inadequate intakes of folate and methionine, may increase risk of colon cancer is supported and similar findings in adenomas are confirmed.

DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation

  • M. CravoP. Fidalgo C. N. Leitão
  • Medicine
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 1994
It is demonstrated that global DNA hypomethylation occurs in normal rectal mucosa from patients with colorectal neoplasms as compared with controls, and that it was significantly reduced with pharmacological doses of folk add.

Colorectal cancer and folate status: a nested case-control study among male smokers.

  • S. GlynnD. Albanes P. Taylor
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1996
There is a possible association between low folate intake and increased risk of colon cancer (but not rectal cancer) and the need for further studies that measure dietary folate and methionine, along with biochemical measures of folate (i.e., erythrocyte and serum), homocysteine, and vitamin B12 is highlighted.