Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat.

@article{Russell2000BeneficialIA,
  title={Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat.},
  author={James C. Russell and Denis Ravel and J. P. Pegorier and P Delrat and R. Jochemsen and Sheila F O'brien and Sandra E. Kelly and Sandra T Davidge and David N. Brindley},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 2},
  pages={753-60}
}
S15261, a compound developed for the oral treatment of type II diabetes, is cleaved by esterases to the fragments Y415 and S15511. The aim was to define the insulin-sensitizing effects of S15261, the cleavage products, and troglitazone and metformin in the JCR:LA-cp rat, an animal model of the obesity/insulin resistance syndrome that exhibits an associated vasculopathy and cardiovascular disease. Treatment of the animals from 8 to 12 weeks of age with S15261 or S15511 resulted in reductions in… CONTINUE READING