Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep.

@article{Rademaker2002BeneficialHE,
  title={Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep.},
  author={Miriam Tessa Rademaker and Christopher John Charles and E A Espiner and Steve Fisher and Chris Frampton and Carl M. J. Kirkpatrick and John G. Lainchbury and M. G. Nicholls and Arthur Mark Richards and Wylie W. Vale},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={40 8},
  pages={1495-505}
}
OBJECTIVES The goal of this study was to determine the bioactivity of urocortin (Ucn) in experimental heart failure (HF). BACKGROUND Urocortin may participate in cardiovascular function and pressure/volume homeostasis. Its effects in HF are unknown. METHODS Eight normal sheep and eight sheep with pacing-induced HF received ovine Ucn (10, 50, and 100 mg intravenous boluses at 2-h intervals) in vehicle-controlled studies. RESULTS Urocortin boluses dose-dependently increased plasma Ucn (p… CONTINUE READING

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The role of urocortins in the cardiovascular system.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2014
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