Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)

@article{Maini1995BeneficialEO,
  title={Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)},
  author={Ravinder N. Maini and Michael J. Elliott and Fionula Mary Brennan and Marc Feldmann},
  journal={Clinical and experimental immunology},
  year={1995},
  volume={101 2},
  pages={207-12}
}
The biological properties of TNF-alpha make it a candidate therapeutic target in RA. Our studies have demonstrated that TNF-alpha and its receptors are up-regulated and co-expressed in the synovium and cartilage-pannus junction of RA joints. Neutralizing TNF-alpha antibodies reduce the production of the many pro-inflammatory cytokines, including IL-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF), produced by mononuclear cells from RA in culture. When injected into DBA/1 mice… CONTINUE READING

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