Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle


The administration of a single dose of monocrotaline (105 mg/kg) after 21 days produced in rats a reduction of cardiac mitochondrial function at the level of complexes I, II and IV of the respiratory chain, associated with the formation of heart hypertrophy, prevalently of the right ventricle. Moreover, in these rats, the submitochondrial particles produced… (More)
DOI: 10.1007/BF00051282


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