Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)

  title={Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)},
  author={Tangui Maurice and Francois J Roman and Tsung-Ping Su and Alain M. Privat},
  journal={Brain Research},

Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

PS induces delayed memory deficits, affecting spatial and nonspatial, short‐ and long‐term memories in juvenile male and female offspring rats, and Activation of the σ1 neuromodulatory receptor allows a significant recovery of the memory functions in PS rats.

Senescence-accelerated mouse (SAM) as an animal model of senile dementia: pharmacological, neurochemical and molecular biological approach.

The neuropathological, neurochemical and pharmacological features of SAM are reported, especially for SAMP8, and the effects of several drugs on the biochemical and behavioral alterations in SAMP9 and the etiologic manifestation of accelerated senescence are discussed.

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

Results confirm that N-acetylcysteine delays the senescence process by slowing the age-related hearing loss, protecting the cochlear hair cells and improving memory, suggesting that antioxidants could be a pharmacological target for age- related hearing and memory loss.



Nicotine imptoves cognitive disturbance in senescence-accelerated mice

Learning impairment following acute administration of the calcium channel antagonist nimodipine in mice

Results show that acute nimodipine administration alters learning in adult mice, and argue for an involvement of voltage-dependent Ca2+ channels, in learning.

Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse.

A lack of age-related changes in food, water, and milk consumption suggests that changes in motivation do not account for the decline in learning in older P/8if mice and suggests an early onset of impaired learning relative to the 17.2-month median life span.