Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)

@article{Maurice1996BeneficialEO,
  title={Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)},
  author={Tangui Maurice and Francois J Roman and Tsung-Ping Su and Alain M. Privat},
  journal={Brain Research},
  year={1996},
  volume={733},
  pages={219-230}
}
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63 Citations
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63 Citations

Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats.

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PS induces delayed memory deficits, affecting spatial and nonspatial, short‐ and long‐term memories in juvenile male and female offspring rats, and Activation of the σ1 neuromodulatory receptor allows a significant recovery of the memory functions in PS rats.

Senescence-accelerated mouse (SAM) as an animal model of senile dementia: pharmacological, neurochemical and molecular biological approach.

The neuropathological, neurochemical and pharmacological features of SAM are reported, especially for SAMP8, and the effects of several drugs on the biochemical and behavioral alterations in SAMP9 and the etiologic manifestation of accelerated senescence are discussed.

Ethological analysis of the senescence-accelerated P/8 mouse

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse

Beneficial effects of the sigma1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine.

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

Results confirm that N-acetylcysteine delays the senescence process by slowing the age-related hearing loss, protecting the cochlear hair cells and improving memory, suggesting that antioxidants could be a pharmacological target for age- related hearing and memory loss.

SA4503, a novel cognitive enhancer with sigma1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice.

...

References

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Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory

Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM)

Nicotine imptoves cognitive disturbance in senescence-accelerated mice

PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

Behavioral evidence for a modulating role of σ ligands in memory processes. II. Reversion of carbon monoxide-induced amnesia

Learning impairment following acute administration of the calcium channel antagonist nimodipine in mice

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