Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity

@article{DeMarch2007BeneficialEO,
  title={Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity},
  author={Zena DeMarch and Carmela Giamp{\`a} and Stefano Patassini and Alessandro Martorana and Francesca R Fusco},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={266-273}
}
Activity of c-AMP responsive element-binding protein (CREB) is decreased in Huntington's disease (HD). Such decrease was also described by our group in the quinolinic acid lesion model of striatal excitotoxicity. The phosphodiesterase type IV inhibitor rolipram increases CREB phosphorylation. Such drug has a protective effect in global ischaemia and embolism in rats. In this study, we sought to determine whether rolipram displays a neuroprotective effect in our rat model of HD. Animals were… CONTINUE READING

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