Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats

@inproceedings{Ma2017BeneficialEO,
  title={Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats},
  author={Zhihong Ma and Li Li Chu and Hongying Liu and Weijie Wang and Jieru Li and Wenzao Yao and Jianfeng Yi and Yue Gao},
  booktitle={Scientific reports},
  year={2017}
}
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver diseases. This study sought to evaluate the insulin-sensitizing effect of paeoniflorin (PF) on high-fat diet-induced NAFLD and possible molecular mechanisms. Male Sprague Dawley rats were fed a high-fat diet (HFD) for 10 weeks to establish the NAFLD model, and PF (20 mg/kg/d) was gavaged to the NAFLD rats for another four weeks. Our results demonstrated that HFD resulted in hepatocellular ballooning, micro… CONTINUE READING
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The authors declare no competing financial interests

  • N. V. Carroll, R. W. Longley, +14 authors approved the final manuscript. Additional Information Compe Interests
  • How to cite this article: Ma, Z. et al…
  • 2017

Involvement with the ROCK/NF-kappaB pathway

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