Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries

@article{Walker2013BeneficialEO,
  title={Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries},
  author={Ashley E. Walker and Grant D. Henson and Kelly D. Reihl and Elizabeth I. Nielson and R Garrett Morgan and Lisa A. Lesniewski and Anthony J Donato},
  journal={AGE},
  year={2013},
  volume={36},
  pages={559-569}
}
Endothelial dysfunction occurs in conduit and cerebral resistance arteries with advancing age. Lifelong caloric restriction (CR) can prevent the onset of age-related dysfunction in many tissues, but its effects on cerebral resistance artery function, as compared with conduit artery function, have not been determined. We measured endothelium-dependent dilation (EDD) in the carotid artery and middle cerebral artery (MCA) from young (5–7 months), old ad libitum fed (AL, 29–32 months), and old… CONTINUE READING

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