Beneficial effects of insulin-like growth factor I on epithelial structure and function in parenterally fed rat jejunum.

@article{Peterson1996BeneficialEO,
  title={Beneficial effects of insulin-like growth factor I on epithelial structure and function in parenterally fed rat jejunum.},
  author={Catherine A. Peterson and Denise M Ney and Pamela Sue Hinton and Hannah V Carey},
  journal={Gastroenterology},
  year={1996},
  volume={111 6},
  pages={1501-8}
}
BACKGROUND & AIMS The functional significance of intestinal hyperplasia stimulated by insulin-like growth factor (IGF)-I is unclear and has not been studied in a model of mucosal atrophy induced by total parenteral nutrition (TPN). The aim of this study was to determine how IGF-I affects intestinal structure and epithelial function in the absence of luminal nutrition caused by TPN. METHODS Rats were maintained with TPN with or without IGF-I (800 micrograms/day), and jejunal histology and… CONTINUE READING

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