Beneficial effects of fibrates on apolipoprotein A-I metabolism occur independently of any peroxisome proliferative response.

@article{Hennuyer1999BeneficialEO,
  title={Beneficial effects of fibrates on apolipoprotein A-I metabolism occur independently of any peroxisome proliferative response.},
  author={Nathalie Hennuyer and Philippe Poulain and Lise Madsen and Rolf Kristian Berge and Louis Marie Houdebine and Didier Branellec and J. C. Fruchart and Catherine Fi{\'e}vet and Nicolas Duverger and Bart Staels},
  journal={Circulation},
  year={1999},
  volume={99 18},
  pages={2445-51}
}
BACKGROUND In humans, fibrates are frequently used normolipidemic drugs. Fibrates act by regulating genes involved in lipoprotein metabolism via activation of the peroxisome proliferator-activated receptor-alpha (PPARalpha) in liver. In rodents, however, fibrates induce a peroxisome proliferation, leading to hepatomegaly and possibly hepatocarcinogenesis. Although this peroxisome proliferative response appears not to occur in humans, it remains controversial whether the beneficial effects of… CONTINUE READING