Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease

@inproceedings{Skillings2014BeneficialEO,
  title={Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease},
  author={Elizabeth A. Skillings and Nigel I. Wood and A. Jennifer Morton},
  booktitle={Brain and behavior},
  year={2014}
}
BACKGROUND In addition to their cognitive and motor deficits, R6/2 mice show a progressive disintegration in circadian rhythms that mirrors the problems associated with sleep-wake disturbances experienced by patients with Huntington's disease (HD). It has been shown previously that motor and cognitive performance, as well as survival, can be improved in transgenic mouse models of HD through the provision of environmental enrichment. METHODS We compared the effect of two different overnight… CONTINUE READING
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Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.

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