Beneficial effects of elevating cardiac preload on left-ventricular diastolic function and volume during heat stress: implications toward tolerance during a hemorrhagic insult.

@article{Brothers2014BeneficialEO,
  title={Beneficial effects of elevating cardiac preload on left-ventricular diastolic function and volume during heat stress: implications toward tolerance during a hemorrhagic insult.},
  author={R Matthew Brothers and Redi Pecini and Morten Dalsgaard and Morten Bundgaard-Nielsen and Thad E Wilson and Niels Secher and Craig G Crandall},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2014},
  volume={307 8},
  pages={R1036-41}
}
Volume loading normalizes tolerance to a simulated hemorrhagic challenge in heat-stressed individuals, relative to when these individuals are thermoneutral. The mechanism(s) by which this occurs is unknown. This project tested two unique hypotheses; that is, the elevation of central blood volume via volume loading while heat stressed would 1) increase indices of left ventricular diastolic function, and 2) preserve left ventricular end-diastolic volume (LVEDV) during a subsequent simulated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS