Beneficial effects of danazol on symptoms and laboratory changes in cholinergic urticaria

@article{Wong1987BeneficialEO,
  title={Beneficial effects of danazol on symptoms and laboratory changes in cholinergic urticaria},
  author={Eric Wong and Nahid Eftekhari and M. W. Greaves and Anthony Milford Ward},
  journal={British Journal of Dermatology},
  year={1987},
  volume={116}
}
In a double‐blind placebo‐controlled study, danazol, an attenuated androgen, was effective in reducing exercise‐induced weals in cholinergic urticaria. Danazol treatment also caused significant elevations of several protease inhibitors, particularly antichymotrypsin which has been reported previously to be low in cholinergic urticaria. 

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A case of refractory cholinergic urticaria who had an adequate response to danazol and ketotifen is presented, thereby proving to be an effective therapy in patients who don ́t respond to conventional therapy and without access to biological treatment.

Cholinergic Urticaria and Exercise-Induced Anaphylaxis

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This case demonstrated a dramatic symptomatic response to danazol which has not previously been reported and strongly supports the view that all three syndromes are variations of the same disease.

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TLDR
There was considerable variability, particularly in the cold urticaria which was of the common cold contact type in seven patients, of the generalized cold induced cholinergic type in two and in four patients the lesions induced by direct contact with ice were morphologically like cholinery, but appeared despite prior application of an acetyl choline antagonist.

Alternative treatments for severely affected patients with urticaria.

  • L. Juhlin
  • Medicine
    The journal of investigative dermatology. Symposium proceedings
  • 2001
TLDR
In all types of urticaria it is important to work with the patient and try to eradicate the cause or inhibit the mediators giving the clinical signs to stop the progression of the disease.

Successful treatment of disabling cholinergic urticaria.

TLDR
A 22-year-old African American U.S. sailor presented with an intermittent pruritic eruption precipitated by mild activity for the last 2 years, and was diagnosed with cholinergic urticaria, successfully controlled with a combination of cetirizine, montelukast, and propanolol.
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References

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TLDR
In patients with cholinergic urticaria, exercise proved the simplest, most effective diagnostic test and intradermal testing is not always reproducible in the same patient.

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TLDR
Danazol effectively prevents attacks in hereditary angioedema and acts to correct the underlying biochemical abnormality and side effects were minimal.

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TLDR
Danazol effectively prevents attacks in hereditary angioedema and acts to correct the underlying biochemical abnormality and side effects were minimal.

Protease inhibitor profiles in urticaria and angio‐oedema

TLDR
Patients with chronic urticaria/angio‐oedema showed a reduction in inter‐α trypsin inhibitor and a rise in C1 esterase inhibitor and the elevated levels of α2 macroglobulin in the three groups are probably due to differences in the mean age of these groups compared with the reference population.

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TLDR
Nine patients with hereditary angio‐oedema with a deficiency of C1 esterase inhibitor, have been treated with low dose attenuated androgenic drugs with complete control of their disease, and it is concluded that H. A. E. can be controlled in the absence of correction of the reduced levels of C 1 INH and C4.

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TLDR
It is demonstrated that serum alpha1-antitrypsin levels can be augmented by danazol therapy in PiZ individuals as well as those heterozygotes with severe deficiency of alpha 1-ant itypsin.