Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia.

@article{Napoli2008BeneficialEO,
  title={Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia.},
  author={Claudio Napoli and Bartolomeo Farzati and Vincenzo Sica and Emanuele Iannuzzi and Giuseppe Coppola and Andrea Silvestroni and Maria Luisa Balestrieri and Anna Paola Florio and Angelo Matarazzo},
  journal={European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology},
  year={2008},
  volume={15 6},
  pages={
          709-18
        }
}
BACKGROUND Short-term (within 6 weeks follow-up) clinical studies indicate that implantation of bone marrow cells (BMCs) into ischemic limbs may improve peripheral ischemia. Here, the long-term safety and feasibility of intraarterial autologous BMCs with oral treatment with antioxidants and L-arginine were investigated in patients with critical ischemia on account of advanced atherosclerotic peripheral arterial disease (PAD). METHODS Eighteen patients with PAD (advanced III/IV Fontaine stages… CONTINUE READING
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