Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

@article{Kaneto1999BeneficialEO,
  title={Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.},
  author={Hideaki Kaneto and Yoshitaka Kajimoto and Jun-ichiro Miyagawa and T a Matsuoka and Yoshio Fujitani and Yutaka Umayahara and Toshiaki Hanafusa and Yoshimasa Matsuzawa and Yoshimitsu Yamasaki and M Hori},
  journal={Diabetes},
  year={1999},
  volume={48 12},
  pages={
          2398-406
        }
}
Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with diabetes. The aim of this study was to examine the involvement of oxidative stress in the progression of pancreatic beta-cell dysfunction in type 2 diabetes and to evaluate the potential usefulness of antioxidants in the treatment of type 2 diabetes. We used diabetic C57BL/KsJ-db/db mice, in whom antioxidant treatment (N-acetyl-L-cysteine [NAC], vitamins C plus E, or both… CONTINUE READING

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