Beneficial effects of angiotensin (1-7) in diabetic rats with cardiomyopathy.

@article{Singh2011BeneficialEO,
  title={Beneficial effects of angiotensin (1-7) in diabetic rats with cardiomyopathy.},
  author={Kulwinder Singh and Tajinder Singh and P. L. Sharma},
  journal={Therapeutic advances in cardiovascular disease},
  year={2011},
  volume={5 3},
  pages={159-67}
}
OBJECTIVE This study was designed to investigate the effect of angiotensin (1-7), a Mas receptor agonist, and A-779, a Mas receptor antagonist, in rats with diabetic cardiomyopathy (DC). METHODS Rats treated with a single injection of streptozotocin (50 mg/kg, intraperitoneal), developed DC after 8 weeks. The extent of DC was assessed by measuring the left ventricular weight/body weight (LVW/BW) ratio, absolute LVW, left ventricular developed pressure (LVDP), maximum change in left… CONTINUE READING

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