Beneficial effects of aldosterone blockade in a mouse model of lupus nephritis

  • Published 2008 in Nature Clinical Practice Rheumatology

Abstract

Systemic administration of either compound suppressed CIA without causing obvious immunosuppression or adverse effects. Both compounds showed similar results, which suggests that CDK4 + CDK6 are involved in pannus formation. In previous clinical anticancer trials, alvocidib induced apoptosis of malignant cells, but in CIA this drug arrested synovial… (More)
DOI: 10.1038/ncprheum0780

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