Beneficial effects of aldosterone blockade in a mouse model of lupus nephritis

  • Published 2008 in Nature Clinical Practice Rheumatology


Systemic administration of either compound suppressed CIA without causing obvious immunosuppression or adverse effects. Both compounds showed similar results, which suggests that CDK4 + CDK6 are involved in pannus formation. In previous clinical anticancer trials, alvocidib induced apoptosis of malignant cells, but in CIA this drug arrested synovial… (More)
DOI: 10.1038/ncprheum0780


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