Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage.

@article{Bedke2007BeneficialEO,
  title={Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage.},
  author={Jens Bedke and {\'E}va {\'I}risz Kiss and Liliana Schaefer and C-L Behnes and Mahnaz Bonrouhi and Norbert Gretz and Richard Horuk and Maria Diedrichs-Moehring and Gerhild Wildner and Peter J. Nelson and Hermann Josef Groene},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2007},
  volume={7 3},
  pages={527-37}
}
The biology of chemokines and their receptors have been linked to the development of chronic allograft damage. Effects of CCR1 antagonist BX 471 were studied in a Fischer to Lewis renal transplantation model at days 10, 21 and 42 after transplantation. BX 471 treatment did not effectively reduce signs of acute rejection at day 10 but significantly improved allograft function and morphology at day 21 posttransplantation. When therapy was initiated on day 21 after transplantation… CONTINUE READING
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