Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart.

@article{Gourine2008BeneficialEO,
  title={Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart.},
  author={Alexander V. Gourine and Svetlana I Bondar and K. M. Spyer},
  journal={Circulation research},
  year={2008},
  volume={102 6},
  pages={633-6}
}
Heart failure patients are routinely given beta-adrenoceptor antagonists (beta-blockers), although the mechanism(s) underlying their beneficial effects is not fully resolved. It is not entirely clear how long-term application of negative inotropic compounds improves cardiac performance, slows remodeling processes, and decreases mortality. All beta-blockers, which produce a beneficial effect in heart failure, have in common a high degree of lipophilicity and, therefore, have the ability to cross… CONTINUE READING
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