• Corpus ID: 43939175

Beneficial effect of lycopene against lifestyle induced male infertility-06

  title={Beneficial effect of lycopene against lifestyle induced male infertility-06},
  author={Sanjay Nathmal Agrawal},

Effect of Lycopene Supplementation on Infertility in Men: A Systematic Review on Clinical Trial Studies

The aim of this study was to summarize the data from clinical trial articles on the effects of lycopene supplementation on different parameters of sperm in infertile men.



The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy.

Adequately powered, placebo-controlled comprehensive clinical trials are now required to establish a clear role for antioxidants in the prevention of oxidative stress in the male germ line, such that the clinical utility of this form of therapy becomes established once and for all.

Lycopene and male infertility: do we know enough?

In a randomized controlled trial, lycopene supplementation in moderately overweight, disease-free, middle aged adults showed no significant changes in markers of cardiovascular disease, which do not justify potential health claims that lycopenes supplementation has a cardioprotective effect.

Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects

In sedentary individuals with different ranges of BMI, Glutathione Reductase and distinct cytokines are differentially involved into the adaptive metabolic changes and redox responses induced by physical exercise, suggesting individuals at higher risk for developing diseases pathophysiologically linked to oxidative stress.

Lipid peroxidation and tissue damage.

Lipid peroxidation has been implicated in disease states such as atherosclerosis, IBD, ROP, BPD, asthma, Parkinson's disease, kidney damage, preeclampsia and others.

A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men

A Randomized controlled trial of lycopene treatment on soluble receptor for advanced glycation end products in seminal and blood plasma of normospermic men shows promising results.

Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus.

The presence of RAGE implies that it may play a central role in sperm nDNA damage particularly in diabetic men where the levels are elevated.

The Semen pH Affects Sperm Motility and Capacitation

The results suggested that the declined Na+/K+-ATPase activity at acidic pHs result in decreased sperm movement and capacitation, which could be one of the mechanisms of male infertility.

Lycopene and male infertility

Improvement in sperm parameters and pregnancy rates with supplementation of 4–8 mg of lycopene daily for 3–12 months indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg.

Lycopene therapy in idiopathic male infertility – a preliminary report

Oral Lycopene therapy seem to have a role in the management of idiopathicmale infertility and maximum improvement seems tooccur in the sperm concentration, although largerrandomised controlled trials are essential before definitive therapeutic guidelines can be made.

Redox Mechanism of Reactive Oxygen Species in Exercise

This review updates on new findings of ROS origins within skeletal muscles associated with various types of exercises such as endurance, sprint and mountain climbing and examines the corresponding antioxidant defense systems as well as dietary manipulation against damages caused by ROS.