Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta.

AIM To find an effective symptomatic treatment for osteogenesis imperfecta (OI). METHODS In a prospective observational study disodium pamidronate (APD) was given as monthly intravenous infusions to 28 children and adolescents (aged 0.6-18 years) with severe OI or a milder form of the disease, but with spinal compression fractures. RESULTS During… CONTINUE READING