Beneficial effect of enhanced macrophage function in the trauma patient.

  title={Beneficial effect of enhanced macrophage function in the trauma patient.},
  author={William Browder and Dallas Williams and H A Pretus and Giuseppe Olivero and F Enrichens and Pei-lin Mao and Alessandro Franchello},
  journal={Annals of surgery},
  volume={211 5},
  pages={605-12; discussion 612-3}
Host immunosuppression after trauma contributes to septic morbidity. The macrophage is a key element in the host immune response. This study evaluated glucan, a macrophage stimulant, in a prospective, randomized, double-blind study of 38 trauma patients undergoing surgery. Glucan (21 patients), 50 mg/m2, or placebo (17 patients) was given intravenously daily for 7 days. Delayed hypersensitivity skin testing was performed on days 1 and 7 after trauma. Serum interleukin-1 (IL-1) and tumor… CONTINUE READING
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