Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia

@inproceedings{Wang2010BeneficialEO,
  title={Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia},
  author={Che-Chuan Wang and Chung-Ching Chio and Ching-Hong Chang and Jinn-Rung Kuo and Ching-Ping Chang},
  booktitle={BMC pharmacology},
  year={2010}
}
BACKGROUND Although agmatine therapy in a mouse model of transient focal cerebral ischemia is highly protective against neurological injury, the mechanisms underlying the protective effects of agmatine are not fully elucidated. This study aimed to investigate the effects of agmatine on brain apoptosis, astrogliosis and edema in the rats with transient cerebral ischemia. METHODS Following surgical induction of middle cerebral artery occlusion (MCAO) for 90 min, agmatine (100 mg/kg, i.p.) was… CONTINUE READING
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