Beneficial effect of S-adenosylmethionine during both cold storage and cryopreservation of isolated hepatocytes.


Oxygen free radicals appear to be the prime cell-toxic products during cold preservation. Glutathione (GSH) seems to play a critical role in cell protection against oxidant stress. The experimental decrease of intracellular GSH in vivo may be prevented by the administration of S-adenosylmethionine (SAMe), which seems also to play an important role in… (More)


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